The Differences Between HRT and TRT

brandon llewellyn | 25 March, 2025


          
            The Differences Between HRT and TRT

Hormones play an important role in the normal biological function of men and women. However, hormone production tends to slow later in life, causing unwanted and uncomfortable symptoms.

Replacement therapies can help alleviate these issues and are an effective solution for many patients. Here’s what to know about HRT, TRT, and the importance of quality hormone delivery supplies from a reliable provider.

What is Hormone Replacement Therapy (HRT)?

Hormone replacement therapy (HRT) involves supplementing the estrogen and progesterone a woman's body no longer makes following menopause. Although there are many other hormones, the term “HRT” is generally exclusive to treatment for women.

HRT Types

There are two types of HRT – estrogen-only and combination estrogen/progesterone treatment. Combination treatment is typically used for women who have intact ovaries, while estrogen-only supplementation is reserved for women who have undergone a hysterectomy and no longer have ovaries to produce the hormones they need.

What Does It Treat?

Hormone replacement therapy is typically used totreat menopausal symptoms like:

  • Low mood

  • Irritability

  • Skin dryness

  • Adult acne

  • Increased or new onset anxiety

  • Trouble sleeping

  • Pain during sexual intercourse

  • Vaginal dryness

  • Night sweats

  • Hot flashes

  • Weight gain

Administration Methods

Estrogen and progesterone can be administered a variety of ways, including:

  • Oral tablets taken by mouth at the same time every day

  • Intramuscular injections administered in a doctor’s office

  • Apellet implant under the skin that releases hormones slowly over a period of time

  • A patch placed on top of the skin that also releases hormones over time

  • Gels, sprays, and other topical ointments that can be applied to the skin

  • Insertable rings or suppositories placed in the vagina behind the cervix

The best route of administration depends on the patient and their physician’s recommendations.

Risks & Side Effects

While hormone replacement therapy is generally considered safe and well-tolerated by most people, there are some uncommon risks and potentialside effects to be aware of, like:

  • Headaches

  • Nausea and vomiting

  • Breast tenderness

  • Itchy skin

  • Rash

  • Vaginal spotting or bleeding

  • Mood swings

  • Depression

  • Leg cramps

  • Hair loss

  • Diarrhea

  • Fatigue

  • Dizziness

  • Adult acne

In rare cases, HRT may be associated with a minor increase in the risk of blood clots, deep vein thrombosis, and breast cancer. In most cases, however, the benefits of hormone replacement outweigh the risks.

What is Testosterone Replacement Therapy (TRT)?

Testosterone replacement therapy (TRT) is sometimes called androgen replacement therapy and involves the supplementation of testosterone for men with low testosterone levels and some post-menopausal women with low sexual desire.

TRT Types

There are two types of testosterone that can be used for TRT –synthetic and bioidentical testosterone. Synthetic hormones are usually obtained from animal hormones and have bovine, porcine, or other sources. While this isn't exactly the same as human testosterone, they are considered close enough to be equally as effective.

Bioidentical hormones are obtained from other natural sources like soy and are designed to replicate the same chemical composition of hormones that are organically made by the body. Benefits of bioidentical hormone therapy can include:

  • Improved testosterone levels

  • Reduced genital dryness

  • Heightened sex drive

  • Lowered the risk of osteoporosis

  • Improved muscle mass in men

  • Reduced erectile dysfunction

  • Improved energy levels

  • Increased sleep quality

  • Decreased night sweats and hot flashes

  • Reduced brain fog

  • Increased libido

What Does It Treat?

Typically, testosterone replacement therapy is used for men who are experiencing testosterone deficiency who are also showing signs of hypogonadism like reduced libido, lower stamina during sex, fatigue, high cholesterol, diminished penile sensitivity, or the inability to attain orgasm. This is called andropause and is like a “malemenopause.”

Signs of andropause in men include:

  • Irritability

  • Rapid mood swings

  • Exercise intolerance

  • Muscle atrophy

  • Fatigue

  • Lack of enthusiasm

  • Gynecomastia (male breasts)

  • Increased abdominal fat

  • Insomnia

  • Difficulty concentrating

  • Short-term memory loss

To receive TRT, males must have a blood test that shows testosterone levels below 300 nanograms per deciliter along with disruptive symptoms.

Administration Methods

There are multiple ways that testosterone can be administered, including:

With topical solutions, care must be used to prevent contact with other people, since they could also absorb the medicine through their skin. This makes injectable and implantable testosterone treatments a better option for many people who prefer to avoid this concern.

Risks & Side Effects

Like with all medical procedures and medications, TRT has a few risks and potential side effects to know about, including:

  • Worsened prostate cancer

  • Decreased prostate volume

  • Male breast cancer

  • Obstructive sleep apnea

  • Polycythemia

  • Benign prostatic hyperplasia

  • Liver toxicity

  • Oily skin

  • Bloating

  • Changes in urination

  • High red blood cell counts

  • Mood swings

  • Hair loss

  • Sperm count reduction

  • Increased irritability and aggression

  • Swelling of the ankles and feet

Most serious side effects associated with TRT can be caught early and treated with regular blood tests to check testosterone levels, prostate cancer markers, red blood cells, and liver enzymes. With proper management, TRT can be life-changing for people who are suffering from the uncomfortable or debilitating symptoms of hormone loss.

HRT vs TRT: What's the Difference?

Most of the time, when physicians refer to HRT, they mean estrogen and progesterone replacement therapy for women. When referring to TRT, they typically mean testosterone supplementation for men. The purpose of both treatments is to restore the body’s natural hormone levels while reducing the presence of side effects from either low hormones or the treatment itself.

Trocar Supplies: Ensuring Quality & Reliability in HRT & TRT Delivery

Trocar Supplies has been a trusted provider of HRT and TRT pellet insertion tools since 2006 and is proud to offer reliable, cost-effective solutions for physicians across the world. Our kits are registered in the United States, Brazil, and Argentina, and we go the extra mile to ensure you receive tools that are specially customized to suit your needs.

Order your reusable or disposable trocar kits today or contact us at (937) 478-0469 for answers to your important questions about pricing, kit options, and more. You can also browse our product catalog or request a custom kit here.